To deal with this problem, eBay has created 'Anonymous Email Forwarding'. This change will allow you to respond to email from your own email client, while still protecting the sender's privacy and will supposedly be available during October. According to eBay, here's how it works:

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When a member sends you a message through eBay and has chosen to hide their email address, we'll create anonymous email addresses for both you and the sender. You can then reply to emails directly from your email client just like you do for any email. When your response comes back into our systems, our system will forward it to the appropriate recipient. The anonymous email forwarding service will help members communicate easily with one another while preserving the privacy of your email addresses.

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I have a much easier way to dealing with anonymous questioners: I delete them. I figure if someone can't even reveal their email address they probably aren't a serious buyer. Has this cost me some money? Possibly. But the volume of email I receive every day is gigantic and I choose to spend my precious time with people who are serious and professional. Anonymous emails don't fit that definition.